3IAI

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

Summary for 3IAI

• Entry DOI: 10.2210/pdb3iai/pdb
• Related: 1RJ5
• Descriptor: Carbonic anhydrase 9, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (8 entities in total)
• Functional Keywords: carbonic anhydrases, transmembrane proteins, cell membrane, cell projection, disulfide bond, glycoprotein, lyase, membrane, metal-binding, nucleus, phosphoprotein, transmembrane
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 120750.42

Authors

Alterio, V.,Di Fiore, A.,De Simone, G. (deposition date: 2009-07-14, release date: 2009-09-08, Last modification date: 2023-09-06)

• Primary citation: Alterio, V.,Hilvo, M.,Di Fiore, A.,Supuran, C.T.,Pan, P.,Parkkila, S.,Scaloni, A.,Pastorek, J.,Pastorekova, S.,Pedone, C.,Scozzafava, A.,Monti, S.M.,De Simone, G.; Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.; Proc.Natl.Acad.Sci.USA, 106:16233-16238, 2009; PubMed: 19805286; DOI: 10.1073/pnas.0908301106

Experimental method

X-RAY DIFFRACTION (2.2 Å)