3I6W

Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase

Summary for 3I6W

Entry DOI	10.2210/pdb3i6w/pdb
Descriptor	Serine/threonine-protein kinase Chk2 (1 entity in total)
Functional Keywords	ser/thr protein kinase, fha domain, atp-binding, cell cycle, disease mutation, kinase, li-fraumeni syndrome, magnesium, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains	8
Total formula weight	406719.56
Authors	Pavletich, N.P. (deposition date: 2009-07-07, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Cai, Z.,Chehab, N.H.,Pavletich, N.P. Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase. Mol.Cell, 35:818-829, 2009 Cited by PubMed: 19782031 DOI: 10.1016/j.molcel.2009.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation