3I6L

Newly identified epitope N1 derived from SARS-CoV N protein complexed with HLA-A*2402

Summary for 3I6L

• Entry DOI: 10.2210/pdb3i6l/pdb
• Descriptor: HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, Nucleoprotein peptide, ... (4 entities in total)
• Functional Keywords: hla-a*2402, sars-cov, nucleocapsid protein, disulfide bond, glycoprotein, host-virus interaction, immune response, membrane, mhc i, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, golgi apparatus, phosphoprotein, ribonucleoprotein, rna-binding, viral nucleoprotein, virion, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P05534; Secreted: P61769; Virion: P59595
• Total number of polymer chains: 3
• Total formula weight: 44521.54

Authors

Liu, J.W. (deposition date: 2009-07-07, release date: 2010-07-14, Last modification date: 2023-11-01)

• Primary citation: Liu, J.,Wu, P.,Gao, F.,Qi, J.,Kawana-Tachikawa, A.,Xie, J.,Vavricka, C.J.,Iwamoto, A.,Li, T.,Gao, G.F.; Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein; J.Virol., 84:11849-11857, 2010; PubMed: 20844028; DOI: 10.1128/JVI.01464-10

Experimental method

X-RAY DIFFRACTION (2.4 Å)