3HZF

Structure of TR-alfa bound to selective thyromimetic GC-1 in C2 space group

Summary for 3HZF

Entry DOI	10.2210/pdb3hzf/pdb
Descriptor	Thyroid hormone receptor, alpha isoform 1 variant, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid (3 entities in total)
Functional Keywords	nuclear receptor, ligand binding domain, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31334.61
Authors	Aparicio, R.,Bleicher, L.,Polikarpov, I. (deposition date: 2009-06-23, release date: 2009-07-21, Last modification date: 2023-09-06)
Primary citation	Bleicher, L.,Aparicio, R.,Nunes, F.M.,Martinez, L.,Gomes Dias, S.M.,Figueira, A.C.,Santos, M.A.,Venturelli, W.H.,da Silva, R.,Donate, P.M.,Neves, F.A.,Simeoni, L.A.,Baxter, J.D.,Webb, P.,Skaf, M.S.,Polikarpov, I. Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. Bmc Struct.Biol., 8:8-8, 2008 Cited by PubMed: 18237438 DOI: 10.1186/1472-6807-8-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation