3HRF

Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket

Summary for 3HRF

• Entry DOI: 10.2210/pdb3hrf/pdb
• Related: 3HRC
• Descriptor: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid, ... (5 entities in total)
• Functional Keywords: agc kinase, phosphorylation, allostery, pdk1, pif-pocket, alpha-c helix, activation loop, atp binding, atp-binding, kinase, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens
• Cellular location: Cytoplasm: O15530
• Total number of polymer chains: 1
• Total formula weight: 36663.11

Authors

Hindie, V.,Alzari, P.M.,Biondi, R.M. (deposition date: 2009-06-09, release date: 2009-09-15, Last modification date: 2023-11-01)

• Primary citation: Hindie, V.,Stroba, A.,Zhang, H.,Lopez-Garcia, L.A.,Idrissova, L.,Zeuzem, S.,Hirschberg, D.,Schaeffer, F.,Jrgensen, T.J.,Engel, M.,Alzari, P.M.,Biondi, R.M.; Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.; Nat.Chem.Biol., 5:758-764, 2009; PubMed: 19718043; DOI: 10.1038/nchembio.208

Experimental method

X-RAY DIFFRACTION (1.9 Å)