3HRC

Crystal structure of a mutant of human PDK1 Kinase domain in complex with ATP

Summary for 3HRC

Entry DOI	10.2210/pdb3hrc/pdb
Related	3HRF
Descriptor	3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
Functional Keywords	agc kinase, phosphorylation, allostery, pdk1, activation loop, atp binding, atp-binding, kinase, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	35899.75
Authors	Hindie, V.,Alzari, P.M.,Biondi, R.M. (deposition date: 2009-06-09, release date: 2009-09-15, Last modification date: 2023-11-01)
Primary citation	Hindie, V.,Stroba, A.,Zhang, H.,Lopez-Garcia, L.A.,Idrissova, L.,Zeuzem, S.,Hirschberg, D.,Schaeffer, F.,Jrgensen, T.J.,Engel, M.,Alzari, P.M.,Biondi, R.M. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol., 5:758-764, 2009 Cited by PubMed: 19718043 DOI: 10.1038/nchembio.208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation