3HRB

p38 kinase Crystal structure in complex with small molecule inhibitor

Summary for 3HRB

Entry DOI	10.2210/pdb3hrb/pdb
Descriptor	Mitogen-activated protein kinase 14, [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone (3 entities in total)
Functional Keywords	p38 map kinase, transferase, inhibitor complex, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	41552.32
Authors	Segarra, V.,Lumeras, W.,Vidal, B.,Leonard, P.,Fisher, M.,Lamers, M. (deposition date: 2009-06-09, release date: 2009-09-01, Last modification date: 2023-11-01)
Primary citation	Lumeras, W.,Caturla, F.,Vidal, L.,Esteve, C.,Balague, C.,Orellana, A.,Dominguez, M.,Roca, R.,Huerta, J.M.,Godessart, N.,Vidal, B. Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase J.Med.Chem., 52:5531-5545, 2009 Cited by PubMed: 19678708 DOI: 10.1021/jm9008604 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation