3HKW

HCV NS5B genotype 1a in complex with 1,5 benzodiazepine inhibitor 6

Summary for 3HKW

• Entry DOI: 10.2210/pdb3hkw/pdb
• Related: 3HKY
• Descriptor: NS5B RNA-dependent RNA polymerase, (11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: hcv polymerase, subtype 1a, 1, 5-benzodiazepine, transferase
• Biological source: Hepatitis C virus subtype 1a
• Total number of polymer chains: 3
• Total formula weight: 197081.87

Authors

Nyanguile, O.,De Bondt, H.L. (deposition date: 2009-05-26, release date: 2010-05-26, Last modification date: 2023-11-01)

• Primary citation: Nyanguile, O.,Devogelaere, B.,Vijgen, L.,Van den Broeck, W.,Pauwels, F.,Cummings, M.D.,De Bondt, H.L.,Vos, A.M.,Berke, J.M.,Lenz, O.,Vandercruyssen, G.,Vermeiren, K.,Mostmans, W.,Dehertogh, P.,Delouvroy, F.,Vendeville, S.,VanDyck, K.,Dockx, K.,Cleiren, E.,Raboisson, P.,Simmen, K.A.,Fanning, G.C.; 1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus; J.Virol., 84:2923-2934, 2010; PubMed: 20071590; DOI: 10.1128/JVI.01980-09

Experimental method

X-RAY DIFFRACTION (1.55 Å)