3HKJ

Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

Summary for 3HKJ

Entry DOI	10.2210/pdb3hkj/pdb
Related	1TQ0 3HK3 3HK6 3HKI
Descriptor	Thrombin light chain, Thrombin heavy chain, Proteinase-activated receptor 1, ... (5 entities in total)
Functional Keywords	serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen, cell membrane, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	72298.40
Authors	Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. (deposition date: 2009-05-23, release date: 2009-07-07, Last modification date: 2023-09-06)
Primary citation	Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A. J.Biol.Chem., 284:24098-24105, 2009 Cited by PubMed: 19586901 DOI: 10.1074/jbc.M109.025403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation