3HIH

Structure of human Plk1-PBD with glycerol and sulfate in the phophopeptide binding site

Summary for 3HIH

• Entry DOI: 10.2210/pdb3hih/pdb
• Descriptor: Serine/threonine-protein kinase PLK1, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: kinase, phosphopeptide-binding domain, transferase, serine threonine protein kinase, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 2
• Total formula weight: 52691.85

Authors

Wlodawer, A.,Moulaei, T. (deposition date: 2009-05-20, release date: 2009-06-09, Last modification date: 2024-02-21)

• Primary citation: Yun, S.M.,Moulaei, T.,Lim, D.,Bang, J.K.,Park, J.E.,Shenoy, S.R.,Liu, F.,Kang, Y.H.,Liao, C.,Soung, N.K.,Lee, S.,Yoon, D.Y.,Lim, Y.,Lee, D.H.,Otaka, A.,Appella, E.,McMahon, J.B.,Nicklaus, M.C.,Burke, T.R.,Yaffe, M.B.,Wlodawer, A.,Lee, K.S.; Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.; Nat.Struct.Mol.Biol., 16:876-882, 2009; PubMed: 19597481; DOI: 10.1038/nsmb.1628

Experimental method

X-RAY DIFFRACTION (1.7 Å)