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3H9K

Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry

Summary for 3H9K
Entry DOI10.2210/pdb3h9k/pdb
Related1HVY 1HW3 2RD8 2RDA
DescriptorThymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordstransferase, methyltransferase, nucleotide biosynthesis
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P04818
Total number of polymer chains5
Total formula weight179967.22
Authors
Gibson, L.M.,Lovelace, L.L.,Lebioda, L. (deposition date: 2009-04-30, release date: 2010-05-12, Last modification date: 2023-09-06)
Primary citationGibson, L.M.,Celeste, L.R.,Lovelace, L.L.,Lebioda, L.
Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.
Acta Crystallogr.,Sect.D, 67:60-66, 2011
Cited by
PubMed: 21206062
DOI: 10.1107/S0907444910044732
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

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