3H64

Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with endothall

Summary for 3H64

Entry DOI	10.2210/pdb3h64/pdb
Related	3H60 3H61 3H62 3H63 3H66 3H67 3H68 3H69
Descriptor	Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (4 entities in total)
Functional Keywords	metalloenzyme, phosphatase, inhibitors, drug design, cytoplasm, hydrolase, iron, manganese, metal-binding, nucleus, protein phosphatase, tpr repeat
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P53041
Total number of polymer chains	2
Total formula weight	72493.67
Authors	Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. (deposition date: 2009-04-23, release date: 2009-09-29, Last modification date: 2023-11-01)
Primary citation	Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52:4838-4843, 2009 Cited by PubMed: 19601647 DOI: 10.1021/jm900610k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation