3H1P
Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site
Summary for 3H1P
| Entry DOI | 10.2210/pdb3h1p/pdb |
| Related | 1F1J 1SHJ 1k86 2QLF |
| Related PRD ID | PRD_000422 |
| Descriptor | Caspase-7, N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-[(2S)-1-CARBOXY-3-HYDROXYPROPAN-2-YL]-L-VALINAMIDE (3 entities in total) |
| Functional Keywords | protease, compensatory mechanism, apoptosis, cell death, cysteine protease, thiol protease, zymogen, hydrolase-inhibitor complex, hydrolase/inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm: P55210 |
| Total number of polymer chains | 4 |
| Total formula weight | 60348.12 |
| Authors | Witkowski, W.A.,Hardy, J.A. (deposition date: 2009-04-13, release date: 2009-06-30, Last modification date: 2023-11-22) |
| Primary citation | Witkowski, W.A.,Hardy, J.A. L2' loop is critical for caspase-7 active site formation. Protein Sci., 18:1459-1468, 2009 Cited by PubMed: 19530232DOI: 10.1002/pro.151 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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