3GXM
Crystal structure of acid-beta-glucosidase at pH 4.5, phosphate crystallization condition
Summary for 3GXM
| Entry DOI | 10.2210/pdb3gxm/pdb |
| Related | 3GXF 3GXI |
| Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | hydrolase, alternative initiation, disease mutation, disulfide bond, gaucher disease, glycoprotein, glycosidase, ichthyosis, lipid metabolism, lysosome, membrane, sphingolipid metabolism |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 226135.27 |
| Authors | Lieberman, R.L. (deposition date: 2009-04-02, release date: 2009-05-05, Last modification date: 2020-07-29) |
| Primary citation | Lieberman, R.L.,D'aquino, J.A.,Ringe, D.,Petsko, G.A. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry, 48:4816-4827, 2009 Cited by PubMed: 19374450DOI: 10.1021/bi9002265 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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