3GV5

Human DNA polymerase iota in complex with T template DNA and incoming ddADP

Summary for 3GV5

• Entry DOI: 10.2210/pdb3gv5/pdb
• Related: 3GV7 3GV8
• Descriptor: DNA polymerase iota, 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', 5'-D(P*CP*AP*TP*TP*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', ... (7 entities in total)
• Functional Keywords: y-family polymerase, polymerase iota, error prone replication, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, magnesium, metal-binding, mutator protein, nucleotidyltransferase, nucleus, schiff base, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9UNA4
• Total number of polymer chains: 6
• Total formula weight: 109748.08

Authors

Kirouac, K.N.,Ling, H. (deposition date: 2009-03-30, release date: 2009-06-02, Last modification date: 2017-11-01)

• Primary citation: Kirouac, K.N.,Ling, H.; Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota; Embo J., 28:1644-1654, 2009; PubMed: 19440206; DOI: 10.1038/emboj.2009.122

Experimental method

X-RAY DIFFRACTION (2 Å)