3GT8

Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP

Summary for 3GT8

Entry DOI	10.2210/pdb3gt8/pdb
Descriptor	Epidermal growth factor receptor, Unknown peptide, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	inactive kinase, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	5
Total formula weight	153562.26
Authors	Jura, N.,Endres, N.F.,Engel, K.,Deindl, S.,Das, R.,Lamers, M.H.,Wemmer, D.E.,Zhang, X.,Kuriyan, J. (deposition date: 2009-03-27, release date: 2009-07-21, Last modification date: 2024-02-21)
Primary citation	Jura, N.,Endres, N.F.,Engel, K.,Deindl, S.,Das, R.,Lamers, M.H.,Wemmer, D.E.,Zhang, X.,Kuriyan, J. Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell(Cambridge,Mass.), 137:1293-1307, 2009 Cited by PubMed: 19563760 DOI: 10.1016/j.cell.2009.04.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.955 Å)

Structure validation