3GS7

Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13)

Summary for 3GS7

Entry DOI	10.2210/pdb3gs7/pdb
Related	3GLZ 3GS0 3GS4
Descriptor	Transthyretin, 3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acid (3 entities in total)
Functional Keywords	transthyretin, inhibitor, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, polymorphism, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28001.17
Authors	Mohamedmohaideen, N.N.,Palaninathan, S.K.,Orlandini, E.,Sacchettini, J.C. (deposition date: 2009-03-26, release date: 2009-07-28, Last modification date: 2023-09-06)
Primary citation	Palaninathan, S.K.,Mohamedmohaideen, N.N.,Orlandini, E.,Ortore, G.,Nencetti, S.,Lapucci, A.,Rossello, A.,Freundlich, J.S.,Sacchettini, J.C. Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. Plos One, 4:e6290-e6290, 2009 Cited by PubMed: 19621084 DOI: 10.1371/journal.pone.0006290 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation