3GQL

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Summary for 3GQL

• Entry DOI: 10.2210/pdb3gql/pdb
• Related: 3GQI
• Descriptor: Basic fibroblast growth factor receptor 1, (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol (3 entities in total)
• Functional Keywords: phosphorylated kinase, activation, atp analog, atp-binding, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 3
• Total formula weight: 112965.65

Authors

Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J. (deposition date: 2009-03-24, release date: 2009-08-18, Last modification date: 2024-02-21)

• Primary citation: Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J.; The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.; Cell(Cambridge,Mass.), 138:514-524, 2009; PubMed: 19665973; DOI: 10.1016/j.cell.2009.05.028

Experimental method

X-RAY DIFFRACTION (2.8 Å)