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3GOP

Crystal structure of the EGF receptor juxtamembrane and kinase domains

Summary for 3GOP
Entry DOI10.2210/pdb3gop/pdb
DescriptorEpidermal growth factor receptor (2 entities in total)
Functional Keywordskinase, juxtamembrane, egfr, anti-oncogene, atp-binding, cell cycle, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight41667.27
Authors
Choi, S.H.,Alvarado, D.,Moravcevic, K.,Lemmon, M.A. (deposition date: 2009-03-19, release date: 2009-07-07, Last modification date: 2023-09-06)
Primary citationRed Brewer, M.,Choi, S.H.,Alvarado, D.,Moravcevic, K.,Pozzi, A.,Lemmon, M.A.,Carpenter, G.
The juxtamembrane region of the EGF receptor functions as an activation domain.
Mol.Cell, 34:641-651, 2009
Cited by
PubMed: 19560417
DOI: 10.1016/j.molcel.2009.04.034
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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