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3GN8

X-ray Crystal Structure of AncGR2 in Complex with Dexamethasone

Summary for 3GN8
Entry DOI10.2210/pdb3gn8/pdb
DescriptorGlucocorticoid receptor 2, Nuclear receptor coactivator 2, DEXAMETHASONE, ... (4 entities in total)
Functional Keywordsnuclear receptor, gr2, evolution, glucocorticoid receptor, dexamethasone, cortisol, activator, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, hormone-hormone activator complex, hormone/hormone activator
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: 3GN8
Total number of polymer chains4
Total formula weight63087.49
Authors
Ortlund, E.A. (deposition date: 2009-03-16, release date: 2009-09-22, Last modification date: 2023-09-06)
Primary citationBridgham, J.T.,Ortlund, E.A.,Thornton, J.W.
An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
Nature, 461:515-519, 2009
Cited by
PubMed: 19779450
DOI: 10.1038/nature08249
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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