3GIS

Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin

Summary for 3GIS

Entry DOI	10.2210/pdb3gis/pdb
Descriptor	Prothrombin, Thrombomodulin, SULFATE ION, ... (6 entities in total)
Functional Keywords	protein-protein complex, coagulation, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, egf-like domain, hydroxylation, membrane, receptor, thrombophilia, transmembrane, blood clotting
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Membrane; Single-pass type I membrane protein: P07204
Total number of polymer chains	9
Total formula weight	146571.21
Authors	Adams, T.E.,Huntington, J.A. (deposition date: 2009-03-06, release date: 2009-08-18, Last modification date: 2023-11-01)
Primary citation	Adams, T.E.,Li, W.,Huntington, J.A. Molecular basis of thrombomodulin activation of slow thrombin J.Thromb.Haemost., 7:1688-1695, 2009 Cited by PubMed: 19656282 DOI: 10.1111/j.1538-7836.2009.03563.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation