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3GEF

Crystal structure of the R482W mutant of lamin A/C

Summary for 3GEF
Entry DOI10.2210/pdb3gef/pdb
DescriptorLamin-A/C (2 entities in total)
Functional Keywordsimmunoglobulin fold, lamin, cardiomyopathy, charcot-marie-tooth disease, disease mutation, intermediate filament, limb-girdle muscular dystrophy, lipoprotein, nucleus, phosphoprotein, prenylation, structural protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus. Isoform C: Nucleus speckle : P02545
Total number of polymer chains4
Total formula weight52378.45
Authors
Magracheva, E.,Kozlov, S.,Stuart, C.,Wlodawer, A.,Zdanov, A. (deposition date: 2009-02-25, release date: 2009-08-04, Last modification date: 2023-09-06)
Primary citationMagracheva, E.,Kozlov, S.,Stewart, C.L.,Wlodawer, A.,Zdanov, A.
Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD).
Acta Crystallogr.,Sect.F, 65:665-670, 2009
Cited by
PubMed: 19574635
DOI: 10.1107/S1744309109020302
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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