3GCS

Human P38 MAP kinase in complex with Sorafenib

Summary for 3GCS

Entry DOI	10.2210/pdb3gcs/pdb
Related	3GCQ 3GCU
Descriptor	Mitogen-activated protein kinase 14, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	dfg-out, type ii, bay439006, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41992.17
Authors	Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2009-02-22, release date: 2009-06-09, Last modification date: 2023-09-06)
Primary citation	Simard, J.R.,Getlik, M.,Grutter, C.,Pawar, V.,Wulfert, S.,Rabiller, M.,Rauh, D. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. J.Am.Chem.Soc., 131:13286-13296, 2009 Cited by PubMed: 19572644 DOI: 10.1021/ja902010p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation