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3GB9

Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoroadenine

Summary for 3GB9
Entry DOI10.2210/pdb3gb9/pdb
DescriptorPurine nucleoside phosphorylase, 2-fluoroadenine, SULFATE ION, ... (5 entities in total)
Functional Keywordsenzyme-product complex, disease mutation, glycosyltransferase, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton : P00491
Total number of polymer chains3
Total formula weight106922.26
Authors
Sawaya, M.R.,Afshar, S. (deposition date: 2009-02-19, release date: 2009-04-14, Last modification date: 2023-09-06)
Primary citationAfshar, S.,Sawaya, M.R.,Morrison, S.L.
Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.
Protein Sci., 18:1107-1114, 2009
Cited by
PubMed: 19388075
DOI: 10.1002/pro.91
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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