3G90
JNK-3 bound to (Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one
Summary for 3G90
Entry DOI | 10.2210/pdb3g90/pdb |
Related | 3G9L 3G9N |
Descriptor | Mitogen-activated protein kinase 10, (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3 entities in total) |
Functional Keywords | kinase, inhibitor, phosphorylation, atp-binding, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42463.01 |
Authors | Xie, X.,Jacobs, M.D. (deposition date: 2009-02-12, release date: 2009-02-24, Last modification date: 2024-02-21) |
Primary citation | Cao, J.,Gao, H.,Bemis, G.,Salituro, F.,Ledeboer, M.,Harrington, E.,Wilke, S.,Taslimi, P.,Pazhanisamy, S.,Xie, X.,Jacobs, M.,Green, J. Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 19:2891-2895, 2009 Cited by PubMed: 19361991DOI: 10.1016/j.bmcl.2009.03.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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