3G7E

Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor

Summary for 3G7E

Entry DOI	10.2210/pdb3g7e/pdb
Related	3G75 3G7B
Descriptor	DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate (3 entities in total)
Functional Keywords	isomerase, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Escherichia coli
Cellular location	Cytoplasm (By similarity): C3SLN3
Total number of polymer chains	1
Total formula weight	22721.58
Authors	Wei, Y.,Charifson, P. (deposition date: 2009-02-09, release date: 2010-02-09, Last modification date: 2023-09-06)
Primary citation	Ronkin, S.M.,Badia, M.,Bellon, S.,Grillot, A.L.,Gross, C.H.,Grossman, T.H.,Mani, N.,Parsons, J.D.,Stamos, D.,Trudeau, M.,Wei, Y.,Charifson, P.S. Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20:2828-2831, 2010 Cited by PubMed: 20356737 DOI: 10.1016/j.bmcl.2010.03.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation