3G6H

Src Thr338Ile inhibited in the DFG-Asp-Out conformation

Summary for 3G6H

• Entry DOI: 10.2210/pdb3g6h/pdb
• Related: 3G6G
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide (3 entities in total)
• Functional Keywords: cancer, imatinib resistance, dsa compounds, kinase, dfg-asp-out, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
• Biological source: Gallus gallus (chicken)
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 66109.00

Authors

Seeliger, M.A.,Ranjitkar, P.,Kasap, C.,Shan, Y.,Shaw, D.E.,Shah, N.P.,Kuriyan, J.,Maly, D.J. (deposition date: 2009-02-06, release date: 2009-03-24, Last modification date: 2023-09-06)

• Primary citation: Seeliger, M.A.,Ranjitkar, P.,Kasap, C.,Shan, Y.,Shaw, D.E.,Shah, N.P.,Kuriyan, J.,Maly, D.J.; Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations; Cancer Res., 69:2384-2392, 2009; PubMed: 19276351; DOI: 10.1158/0008-5472.CAN-08-3953

Experimental method

X-RAY DIFFRACTION (2.35 Å)