3G60

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

3G60 の概要

• エントリーDOI: 10.2210/pdb3g60/pdb
• 関連するPDBエントリー: 3G5U 3G61
• 分子名称: Multidrug resistance protein 1a, (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (2 entities in total)
• 機能のキーワード: p-glycoprotein, pgp, multidrug resistance, membrane protein, cyclic peptide
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 285170.64

構造登録者

Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G. (登録日: 2009-02-05, 公開日: 2009-03-24, 最終更新日: 2024-02-21)

• 主引用文献: Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G.; Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.; Science, 323:1718-1722, 2009; PubMed: 19325113; DOI: 10.1126/science.1168750

実験手法

X-RAY DIFFRACTION (4.4 Å)