3FZT

Crystal structure of PYK2 complexed with PF-4618433

Summary for 3FZT

• Entry DOI: 10.2210/pdb3fzt/pdb
• Related: 3FZO 3FZP 3FZR 3FZS
• Descriptor: Protein tyrosine kinase 2 beta, 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3H-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1H-pyrazol-5-yl}urea (3 entities in total)
• Functional Keywords: pyk2, kinase, dfg, alternative splicing, atp-binding, cell membrane, cytoplasm, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q14289
• Total number of polymer chains: 1
• Total formula weight: 32635.84

Authors

Han, S. (deposition date: 2009-01-26, release date: 2009-03-31, Last modification date: 2024-02-21)

• Primary citation: Han, S.,Mistry, A.,Chang, J.S.,Cunningham, D.,Griffor, M.,Bonnette, P.C.,Wang, H.,Chrunyk, B.A.,Aspnes, G.E.,Walker, D.P.,Brosius, A.D.,Buckbinder, L.; Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.; J.Biol.Chem., 284:13193-13201, 2009; PubMed: 19244237; DOI: 10.1074/jbc.M809038200

Experimental method

X-RAY DIFFRACTION (1.95 Å)