3FW3

Crystal Structure of soluble domain of CA4 in complex with Dorzolamide

Summary for 3FW3

Entry DOI	10.2210/pdb3fw3/pdb
Related	3F7B 3F7U
Descriptor	Carbonic anhydrase 4, ZINC ION, (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, ... (6 entities in total)
Functional Keywords	structure-based drug design. small molecule complex. co-crystal, cell membrane, disease mutation, glycoprotein, gpi-anchor, lipoprotein, lyase, membrane, metal-binding, polymorphism, retinitis pigmentosa, sensory transduction, vision, zinc
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	61880.93
Authors	Greasley, S.E.,Ferre, R.A.A.,Paz, R.,Wickersham, J. (deposition date: 2009-01-16, release date: 2009-12-01, Last modification date: 2023-09-06)
Primary citation	Vernier, W.,Chong, W.,Rewolinski, D.,Greasley, S.,Pauly, T.,Shaw, M.,Dinh, D.,Ferre, R.A.,Nukui, S.,Ornelas, M.,Reyner, E. Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Bioorg.Med.Chem., 18:3307-3319, 2010 Cited by PubMed: 20363633 DOI: 10.1016/j.bmc.2010.03.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation