3FW0

Structure of Peptidyl-alpha-hydroxyglycine alpha-Amidating Lyase (PAL) bound to alpha-hydroxyhippuric acid (non-peptidic substrate)

Summary for 3FW0

Entry DOI	10.2210/pdb3fw0/pdb
Related	3FVZ
Descriptor	Peptidyl-glycine alpha-amidating monooxygenase, MERCURY (II) ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	beta propeller, zinc, calcium, mercury, lyase, peptide amidation, substrate, hydroxyhippuric acid, alternative splicing, cleavage on pair of basic residues, copper, cytoplasmic vesicle, glycoprotein, membrane, metal-binding, monooxygenase, multifunctional enzyme, oxidoreductase, phosphoprotein, sulfation, transmembrane, vitamin c
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein: P14925
Total number of polymer chains	1
Total formula weight	37550.52
Authors	Chufan, E.E.,De, M.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. (deposition date: 2009-01-16, release date: 2009-09-01, Last modification date: 2024-04-03)
Primary citation	Chufan, E.E.,De, M.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme. Structure, 17:965-973, 2009 Cited by PubMed: 19604476 DOI: 10.1016/j.str.2009.05.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation