3FV8

JNK3 bound to piperazine amide inhibitor, SR2774.

Summary for 3FV8

Entry DOI	10.2210/pdb3fv8/pdb
Descriptor	Mitogen-activated protein kinase 10, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	jnk3, protein-inhibitor complex, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm : P53779
Total number of polymer chains	1
Total formula weight	41740.62
Authors	Habel, J.E. (deposition date: 2009-01-15, release date: 2009-04-07, Last modification date: 2023-09-06)
Primary citation	Shin, Y.,Chen, W.,Habel, J.,Duckett, D.,Ling, Y.Y.,Koenig, M.,He, Y.,Vojkovsky, T.,LoGrasso, P.,Kamenecka, T.M. Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors. Bioorg.Med.Chem.Lett., 19:3344-3347, 2009 Cited by PubMed: 19433357 DOI: 10.1016/j.bmcl.2009.03.086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation