3FV4
Thermolysin inhibition
Summary for 3FV4
| Entry DOI | 10.2210/pdb3fv4/pdb |
| Related | 3ELF 4TMN 5TMN |
| Related PRD ID | PRD_000653 |
| Descriptor | Thermolysin, CALCIUM ION, ZINC ION, ... (7 entities in total) |
| Functional Keywords | protease phosphonamidate inhibitor, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen |
| Biological source | Bacillus thermoproteolyticus |
| Total number of polymer chains | 1 |
| Total formula weight | 35432.01 |
| Authors | Englert, L.,Biela, A.,Heine, A.,Klebe, G. (deposition date: 2009-01-15, release date: 2010-02-09, Last modification date: 2023-09-06) |
| Primary citation | Englert, L.,Biela, A.,Zayed, M.,Heine, A.,Hangauer, D.,Klebe, G. Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: binding of phosphonamidate to the S1'-pocket of thermolysin. Biochim.Biophys.Acta, 1800:1192-1202, 2010 Cited by PubMed: 20600625DOI: 10.1016/j.bbagen.2010.06.009 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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