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3FUH

Leukotriene A4 hydrolase in complex with fragment 5-hydroxyindole and bestatin

Summary for 3FUH
Entry DOI10.2210/pdb3fuh/pdb
Related3FH7 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN
DescriptorLeukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total)
Functional Keywordsleukotriene a4 hydrolase, lta4h, fragment crystallography, fragments of life, fol, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, polymorphism, protease, zinc
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P09960
Total number of polymer chains1
Total formula weight70459.10
Authors
Davies, D.R. (deposition date: 2009-01-14, release date: 2009-07-28, Last modification date: 2023-09-06)
Primary citationDavies, D.R.,Mamat, B.,Magnusson, O.T.,Christensen, J.,Haraldsson, M.H.,Mishra, R.,Pease, B.,Hansen, E.,Singh, J.,Zembower, D.,Kim, H.,Kiselyov, A.S.,Burgin, A.B.,Gurney, M.E.,Stewart, L.J.
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
J.Med.Chem., 52:4694-4715, 2009
Cited by
PubMed: 19618939
DOI: 10.1021/jm900259h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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