3FHR

High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3 (MK3)-inhibitor complex

Summary for 3FHR

Entry DOI	10.2210/pdb3fhr/pdb
Descriptor	MAP kinase-activated protein kinase 3, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE (3 entities in total)
Functional Keywords	kinase-inhibitor complex, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q16644
Total number of polymer chains	1
Total formula weight	38915.36
Authors	Cheng, R.K.Y.,Barker, J.,Palan, S.,Felicetti, B.,Whittaker, M.,Hesterkamp, T. (deposition date: 2008-12-10, release date: 2009-12-15, Last modification date: 2024-03-20)
Primary citation	Cheng, R.,Felicetti, B.,Palan, S.,Toogood-Johnson, I.,Scheich, C.,Barker, J.,Whittaker, M.,Hesterkamp, T. High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand Protein Sci., 19:168-173, 2010 Cited by PubMed: 19937655 DOI: 10.1002/pro.294 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation