3FH8

Leukotriene A4 Hydrolase complexed with inhibitor 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine.

Summary for 3FH8

Entry DOI	10.2210/pdb3fh8/pdb
Related	3FH5 3FH7 3FHE
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total)
Functional Keywords	lta4h, leukotriene a4, leukotriene b4 biosynthesis, peptidase, hydrolase-hydrolase inhibitor complex, structure based drug design, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	70358.02
Authors	Mamat, B.,Davies, D.R. (deposition date: 2008-12-09, release date: 2010-01-05, Last modification date: 2023-09-06)
Primary citation	Sandanayaka, V.,Mamat, B.,Mishra, R.K.,Winger, J.,Krohn, M.,Zhou, L.M.,Keyvan, M.,Enache, L.,Sullins, D.,Onua, E.,Zhang, J.,Halldorsdottir, G.,Sigthorsdottir, H.,Thorlaksdottir, A.,Sigthorsson, G.,Thorsteinnsdottir, M.,Davies, D.R.,Stewart, L.J.,Zembower, D.E.,Andresson, T.,Kiselyov, A.S.,Singh, J.,Gurney, M.E. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53:573-585, 2010 Cited by PubMed: 19950900 DOI: 10.1021/jm900838g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation