3FFG

Factor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE

Summary for 3FFG

• Entry DOI: 10.2210/pdb3ffg/pdb
• Descriptor: Coagulation factor X, heavy chain, Coagulation factor X, light chain, (R)-6-(2'-((3-hydroxypyrrolidin-1-yl)methyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin-7(4h)-one, ... (4 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, blood coagulation, calcium, cleavage on pair of basic residues, protease, secreted
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32651.94

Authors

Alexander, R.A. (deposition date: 2008-12-03, release date: 2009-12-08, Last modification date: 2023-12-27)

• Primary citation: Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R.; Phenyltriazolinones as potent factor Xa inhibitors.; Bioorg.Med.Chem.Lett., 20:1373-1377, 2010; PubMed: 20100660; DOI: 10.1016/j.bmcl.2010.01.011

Experimental method

X-RAY DIFFRACTION (1.54 Å)