3FC8

Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe

Summary for 3FC8

• Entry DOI: 10.2210/pdb3fc8/pdb
• Related: 3FCB
• Descriptor: transthyretin, METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE (3 entities in total)
• Functional Keywords: transthyretin, amyloid, inhibitors, iodine, polymorphism, polyneuropathy, retinol-binding, secreted, hormone binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 27766.30

Authors

Gales, L.,Damas, A.M. (deposition date: 2008-11-21, release date: 2009-02-17, Last modification date: 2023-09-06)

• Primary citation: Mairal, T.,Nieto, J.,Pinto, M.,Almeida, M.R.,Gales, L.,Ballesteros, A.,Barluenga, J.,Perez, J.J.,Vazquez, J.T.,Centeno, N.B.,Saraiva, M.J.,Damas, A.M.,Planas, A.,Arsequell, G.,Valencia, G.; Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.; Plos One, 4:e4124-e4124, 2009; PubMed: 19125186; DOI: 10.1371/journal.pone.0004124

Experimental method

X-RAY DIFFRACTION (1.85 Å)