3F9Z

Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy

Summary for 3F9Z

Entry DOI	10.2210/pdb3f9z/pdb
Related	1ZKK 3F9W 3F9X 3F9Y
Descriptor	Histone-lysine N-methyltransferase SETD8, Histone H4, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywords	methyltransferase, histone, set, lysine, alternative splicing, cell cycle, cell division, chromatin regulator, chromosomal protein, coiled coil, mitosis, nucleus, repressor, s-adenosyl-l-methionine, transcription, transcription regulation, acetylation, dna-binding, methylation, nucleosome core, transferase
Biological source	Homo sapiens More
Cellular location	Nucleus: Q9NQR1 P62805
Total number of polymer chains	8
Total formula weight	81772.90
Authors	Couture, J.-F.,Dirk, L.M.A.,Brunzelle, J.S.,Houtz, R.L.,Trievel, R.C. (deposition date: 2008-11-14, release date: 2008-11-25, Last modification date: 2023-09-06)
Primary citation	Couture, J.F.,Dirk, L.M.,Brunzelle, J.S.,Houtz, R.L.,Trievel, R.C. Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105:20659-20664, 2008 Cited by PubMed: 19088188 DOI: 10.1073/pnas.0806712105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation