3F8E

Coumarins are a novel class of suicide carbonic anhydrase inhibitors

Summary for 3F8E

Entry DOI	10.2210/pdb3f8e/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, disease mutation, lyase, metal-binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30158.09
Authors	Temperini, C.,Maresca, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2008-11-12, release date: 2009-10-06, Last modification date: 2023-11-01)
Primary citation	Maresca, A.,Temperini, C.,Vu, H.,Pham, N.B.,Poulsen, S.-A.,Scozzafava, A.,Quinn, R.J.,Supuran, C.T. Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors J.Am.Chem.Soc., 131:3057-3062, 2009 Cited by PubMed: 19206230 DOI: 10.1021/ja809683v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation