3F7T

Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre

Summary for 3F7T

Entry DOI	10.2210/pdb3f7t/pdb
Descriptor	4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, PYROPHOSPHATE 2-, ... (5 entities in total)
Functional Keywords	pseudo-c3-symmetry; unprecedent fold for fes-cluster proteins, iron, iron-sulfur, isoprene biosynthesis, metal-binding, nadp, oxidoreductase, protein binding
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	74149.34
Authors	Graewert, T.,Eppinger, J.,Rohdich, F.,Bacher, A.,Eisenreich, W.,Groll, M. (deposition date: 2008-11-10, release date: 2009-07-07, Last modification date: 2023-12-27)
Primary citation	Grawert, T.,Rohdich, F.,Span, I.,Bacher, A.,Eisenreich, W.,Eppinger, J.,Groll, M. Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. Angew.Chem.Int.Ed.Engl., 48:5756-5759, 2009 Cited by PubMed: 19569147 DOI: 10.1002/anie.200900548 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation