3F7B

Crystal Structure of soluble domain of CA4 in complex with small molecule.

Summary for 3F7B

• Entry DOI: 10.2210/pdb3f7b/pdb
• Related: 3F7U 3FW3
• Descriptor: Carbonic anhydrase 4, ZINC ION, N-(2-phenylethyl)-2-(phenylsulfanyl)-5-sulfamoylpyridine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: structure-based drug design. small molecule complex. co-crystal., cell membrane, disease mutation, glycoprotein, gpi-anchor, lipoprotein, lyase, membrane, metal-binding, retinitis pigmentosa, sensory transduction, vision, zinc
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Lipid-anchor, GPI-anchor: P22748
• Total number of polymer chains: 2
• Total formula weight: 61686.79

Authors

Greasley, S.E.,Ferre, R.A.A.,Pauly, T.A.,Paz, R. (deposition date: 2008-11-07, release date: 2009-09-22, Last modification date: 2023-09-06)

• Primary citation: Vernier, W.,Chong, W.,Rewolinski, D.,Greasley, S.,Pauly, T.,Shaw, M.,Dinh, D.,Ferre, R.A.,Nukui, S.,Ornelas, M.,Reyner, E.; Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.; Bioorg.Med.Chem., 18:3307-3319, 2010; PubMed: 20363633; DOI: 10.1016/j.bmc.2010.03.014

Experimental method

X-RAY DIFFRACTION (2.05 Å)