3F6K

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin

Summary for 3F6K

Entry DOI	10.2210/pdb3f6k/pdb
Descriptor	Sortilin, Neurotensin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	protein sorting receptor, 10-bladed beta-propeller, cys-rich domains, ssortilin, sortilin vps10p-d, protein-peptide complex, developmental protein, differentiation, endocytosis, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, lysosome, membrane, phosphoprotein, receptor, transmembrane, transport, cytoplasmic vesicle, secreted, signaling protein
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	79703.86
Authors	Quistgaard, E.M.,Madsen, P.,Groftehauge, M.K.,Nissen, P.,Petersen, C.M.,Thirup, S. (deposition date: 2008-11-06, release date: 2008-12-30, Last modification date: 2023-12-27)
Primary citation	Quistgaard, E.M.,Madsen, P.,Groftehauge, M.K.,Nissen, P.,Petersen, C.M.,Thirup, S.S. Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat.Struct.Mol.Biol., 16:96-98, 2009 Cited by PubMed: 19122660 DOI: 10.1038/nsmb.1543 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation