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3F66

Human c-Met Kinase in complex with quinoxaline inhibitor

Summary for 3F66
Entry DOI10.2210/pdb3f66/pdb
DescriptorHepatocyte growth factor receptor, 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol, GAMMA-BUTYROLACTONE, ... (5 entities in total)
Functional Keywordsc-met, protein kinase, quinoxaline, alternative splicing; atp-binding; chromosomal rearrangement; disease mutation; glycoprotein; kinase; membrane; nucleotide-binding; phosphoprotein; polymorphism; proto-oncogene; receptor; repeat; signal; transferase; transmembrane; tyrosine-protein kinase., transferase
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein: P08581
Total number of polymer chains2
Total formula weight68920.69
Authors
Meier, C.,Ceska, T. (deposition date: 2008-11-05, release date: 2008-12-23, Last modification date: 2023-12-27)
Primary citationPorter, J.,Lumb, S.,Lecomte, F.,Reuberson, J.,Foley, A.,Calmiano, M.,le Riche, K.,Edwards, H.,Delgado, J.,Franklin, R.J.,Gascon-Simorte, J.M.,Maloney, A.,Meier, C.,Batchelor, M.
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Bioorg.Med.Chem.Lett., 19:397-400, 2009
Cited by
PubMed: 19059779
DOI: 10.1016/j.bmcl.2008.11.062
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

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