3F4X

Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference

Summary for 3F4X

Entry DOI	10.2210/pdb3f4x/pdb
Related	3BL1
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, diuretics, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29893.83
Authors	Temperini, C.,Cecchi, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2008-11-03, release date: 2009-03-17, Last modification date: 2023-11-01)
Primary citation	Temperini, C.,Cecchi, A.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference. J.Med.Chem., 52:322-328, 2009 Cited by PubMed: 19115843 DOI: 10.1021/jm801386n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation