3F1Q

Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1

Summary for 3F1Q

Entry DOI	10.2210/pdb3f1q/pdb
Descriptor	Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywords	dihydroorotate dehydrogenase, leflunomide, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	40963.45
Authors	Heikkila, T.,Davies, M.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P. (deposition date: 2008-10-28, release date: 2009-06-09, Last modification date: 2023-11-01)
Primary citation	Davies, M.,Heikkila, T.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52:2683-2693, 2009 Cited by PubMed: 19351152 DOI: 10.1021/jm800963t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation