3F18

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-hydroxyethyl)-N-(2-nitroso-2-oxoethyl)benzenesulfonamide

Summary for 3F18

Entry DOI	10.2210/pdb3f18/pdb
Related	3F15 3F16 3F17 3F19 3F1A
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, calcium, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
Biological source	Homo sapiens
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	18025.79
Authors	Calderone, V. (deposition date: 2008-10-27, release date: 2008-11-18, Last modification date: 2023-12-27)
Primary citation	Bertini, I.,Calderone, V.,Fragai, M.,Giachetti, A.,Loconte, M.,Luchinat, C.,Maletta, M.,Nativi, C.,Yeo, K.J. Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases. J.Am.Chem.Soc., 129:2466-2475, 2007 Cited by PubMed: 17269766 DOI: 10.1021/ja065156z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation