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3F0R

Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form

Summary for 3F0R
Entry DOI10.2210/pdb3f0r/pdb
Related3EW8 3EZP 3EZT 3F06 3F07
DescriptorHistone deacetylase 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywordshydrolase, hdac, metalloenzyme, acetylation, arginase fold, hdac8, histone deacetylase 8, hydroxamate inhibitor, alternative splicing, chromatin regulator, nucleus, repressor, transcription, transcription regulation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: Q9BY41
Total number of polymer chains3
Total formula weight131769.85
Authors
Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-25, release date: 2008-12-30, Last modification date: 2023-09-06)
Primary citationDowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W.
Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47:13554-13563, 2008
Cited by
PubMed: 19053282
DOI: 10.1021/bi801610c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.54 Å)
Structure validation

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