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3EZP

Crystal Structure Analysis of human HDAC8 D101N variant

Summary for 3EZP
Entry DOI10.2210/pdb3ezp/pdb
Related3EW8 3EZT
DescriptorHistone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywordshydrolase, hdac, metalloenzyme, arginase fold, hdac8, histone deacetylase 8, hydroxamate inhibitor, mutant, chromatin regulator, nucleus, repressor, transcription, transcription regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight87406.17
Authors
Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-23, release date: 2008-12-30, Last modification date: 2023-09-06)
Primary citationDowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W.
Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47:13554-13563, 2008
Cited by
PubMed: 19053282
DOI: 10.1021/bi801610c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

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