3EXH

Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

Summary for 3EXH

• Entry DOI: 10.2210/pdb3exh/pdb
• Related: 3EXE 3EXF 3EXG 3EXI
• Descriptor: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, MANGANESE (II) ION, ... (8 entities in total)
• Functional Keywords: heterotetramer; thiamine diphosphate-dependent enzyme; disease mutation; glycolysis; leigh syndrome; mitochondrion; oxidoreductase; phosphoprotein; alternative splicing; polymorphism; pyruvate; thiamine pyrophosphate; transit peptide, oxidoreductase
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: P08559 P11177 P08559
• Total number of polymer chains: 8
• Total formula weight: 316673.15

Authors

Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.-C.,Machius, M.,Li, J.,Chuang, D.T. (deposition date: 2008-10-16, release date: 2008-11-25, Last modification date: 2023-12-27)

• Primary citation: Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.C.,Machius, M.,Li, J.,Chuang, D.T.; Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.; Structure, 16:1849-1859, 2008; PubMed: 19081061; DOI: 10.1016/j.str.2008.10.010

Experimental method

X-RAY DIFFRACTION (2.444 Å)